Cytogenetics And Dopamine Receptor (Drd2) Gene Polymorphism In Schizophrenia Patients
نویسندگان
چکیده
منابع مشابه
Study of the association between DRD2 Gene Ser311Cys and GSTM1 Gene polymorphism in Schizophrenia
Introduction: Schizophrenia is a mental disorder affecting 1% of the world's population. Two of genes have been recognized to be involved in development of this disease: DRD2 and GSTM1. Methods: This case-control study included 100 patients suffering from schizophrenia who referred to Yazd Neuropsychiatry Hospital. Also, 100 healthy patients without schizophrenia were selected as the control g...
متن کاملHyperprolactinemia and CYP2D6, DRD2 and HTR2C genes polymorphism in patients with schizophrenia
Introduction: Hyperprolactinemia is a common serious side effect of antipsychotic medications that are currently used in the treatment of patients with schizophrenia. Pharmacogenetic approaches offer the possibility of identifying patient-specific biomarkers for predicting the risk of this side effect. We investigated a possible relationship between variants (SNPs) in genes for cytochrome 2D6 (...
متن کاملhyperprolactinemia and cyp2d6, drd2 and htr2c genes polymorphism in patients with schizophrenia
introduction: hyperprolactinemia is a common serious side effect of antipsychotic medications that are currently used in the treatment of patients with schizophrenia. pharmacogenetic approaches offer the possibility of identifying patient-specific biomarkers for predicting the risk of this side effect. we investigated a possible relationship between variants (snps) in genes for cytochrome 2d6 (...
متن کاملAssessment between Dopamine Receptor D2 (DRD2) Polymorphisms and Schizophrenia in Korean Population
OBJECTIVE The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) of dopamine receptor D2 (DRD2) are associated with schizophrenia in Korean population. METHODS Four SNPs (rs4648317, rs7131056, rs4936270, and rs1076562) of DRD2 were selected and genotyped by direct sequencing in 197 schizophrenia patients and 370 control subjects. SNPAnalyzer, SNPStats, and Hap...
متن کاملDopamine DRD2 polymorphism alters reversal learning and associated neural activity.
In humans, presence of an A1 allele of the DRD2/ANKK1-TaqIa polymorphism is associated with reduced expression of dopamine (DA) D(2) receptors in the striatum. Recently, it was observed that carriers of the A1 allele (A1+ subjects) showed impaired learning from negative feedback in a reinforcement learning task. Here, using functional MRI (fMRI), we investigated carriers and noncarriers of the ...
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ژورنال
عنوان ژورنال: Value in Health
سال: 2015
ISSN: 1098-3015
DOI: 10.1016/j.jval.2015.09.604